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Richard G Ghalie Selected Research

2,2-dimethylbutyric acid

7/2014A double-blind, placebo-controlled phase II study of the efficacy and safety of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.
3/2014A phase 2 trial of HQK-1001 in HbE-β thalassemia demonstrates HbF induction and reduced anemia.
11/2013A dose-escalation phase IIa study of 2,2-dimethylbutyrate (HQK-1001), an oral fetal globin inducer, in sickle cell disease.

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Richard G Ghalie Research Topics

Disease

2Sickle Cell Anemia (Hemoglobin S Disease)
07/2014 - 11/2013
2Thalassemia
03/2014 - 11/2013
2Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
02/2010 - 06/2009
1Pain (Aches)
07/2014
1Fatigue
07/2014
1Headache (Headaches)
07/2014
1Abdominal Pain (Pain, Abdominal)
07/2014
1Nausea
07/2014
1Vomiting
07/2014
1Anemia
03/2014
1B-Cell Lymphoma (Lymphoma, B Cell)
02/2010
1Disease Progression
06/2009
1Neoplasms (Cancer)
07/2004
1Non-Hodgkin Lymphoma (Lymphosarcoma)
07/2004

Drug/Important Bio-Agent (IBA)

32,2-dimethylbutyric acidIBA
07/2014 - 11/2013
2GlobinsIBA
07/2014 - 11/2013
2keyhole-limpet hemocyanin (keyhole limpet hemocyanin)IBA
02/2010 - 06/2009
2Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
02/2010 - 06/2009
2Rituximab (Mabthera)FDA Link
02/2010 - 06/2009
1Volatile Fatty AcidsIBA
07/2014
1Fetal Hemoglobin (Hemoglobin F)IBA
07/2014
1Sickle HemoglobinIBA
11/2013
1Colony-Stimulating Factors (Colony Stimulating Factor)IBA
02/2010
1thiamine triphosphorate (TTP)IBA
06/2009
1Proteins (Proteins, Gene)FDA Link
07/2004
1DOTA-biotin (90Y-DOTA-biotin)IBA
07/2004
1procaine isothiocyanate (PRIT)IBA
07/2004
1Radioisotopes (Radionuclides)IBA
07/2004

Therapy/Procedure

2Immunotherapy
02/2010 - 06/2009
1Injections
02/2010
1Radioimmunotherapy
07/2004